2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2419):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-138599
    5'-O-TBDMS-dA
    		99.89%
    5'-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.
    5'-O-TBDMS-dA
  • HY-108060
    Valopicitabine
    Valopicitabine (NM283) is a nucleoside analog and the orally bioavailable proagent of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination.
    Valopicitabine
  • HY-77645
    4',5'-Didehydro-5'-deoxyuridine
    		99.25%
    4',5'-Didehydro-5'-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    4',5'-Didehydro-5'-deoxyuridine
  • HY-130806
    Dihydrodeoxyuridine
    		98.71%
    Dihydrodeoxyuridine (H2dUrd) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Dihydrodeoxyuridine
  • HY-157549
    Brivoligide
    Brivoligide (AYX1) is a double-stranded, unprotected, 23 base-pair oligonucleotide. Brivoligide can reduce acute post-surgical pain. Brivoligide mimics the DNA sequence normally bound by EGR1 on chromosomes.
    Brivoligide
  • HY-154054
    5′-Azido-5′-deoxyadenosine
    5′-Azido-5′-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 5′-Azido-5′-deoxyadenosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    5′-Azido-5′-deoxyadenosine
  • HY-138616S1
    dGTP-d14 dilithium
    		98.5%
    dGTP-d14 (2'-Deoxyguanosine-5'-triphosphate-d14) dilithium is deuterium labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
    dGTP-d<sub>14</sub> dilithium
  • HY-154214
    2-(3-Methyln-propylidene hydrazino) adenosine
    		99.59%
    2-(3-Methyln-propylidene hydrazino) adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2-(3-Methyln-propylidene hydrazino) adenosine
  • HY-101968
    2'-Deoxypseudoisocytidine
    		Chemical
    2'-Deoxypseudoisocytidine is a nucleoside analogue.
    2'-Deoxypseudoisocytidine
  • HY-138612
    5'-O-DMT-3'-O-TBDMS-Ac-rC
    		99.18%
    5'-O-DMT-3'-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.
    5'-O-DMT-3'-O-TBDMS-Ac-rC
  • HY-152498
    3’-O-(2-Methoxyethyl)adenosine
    		99.87%
    3’-O-(2-Methoxyethyl)adenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    3’-O-(2-Methoxyethyl)adenosine
  • HY-134315
    8-Nitroguanosine
    8-Nitroguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
    8-Nitroguanosine
  • HY-W010771A
    Deoxycytidine triphosphate trisodium,100 mM Solution,PCR Grade
    		99.0%
    Deoxycytidine triphosphate (dCTP; 2′-Deoxycytidine-5′-triphosphate) trisodium,100 mM Solution,PCR Grade is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate trisodium,100 mM Solution,PCR Grade has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing. This product is supplied as an aqueous solution.
    Deoxycytidine triphosphate trisodium,100 mM Solution,PCR Grade
  • HY-B1449S7
    Uridine 13C-4
    		99%
    Uridine 13C-4 is the 13C labeled Uridine.
    Uridine <sup>13</sup>C-4
  • HY-77650
    4'-C-Azidouridine
    4'-C-azidouridine (4'-Azidouridine) is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents. 4'-C-Azidouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    4'-C-Azidouridine
  • HY-138595
    5'-O-TBDMS-Bz-dA
    		98.37%
    5'-O-TBDMS-Bz-dA is a nucleoside with protective and modification effects.
    5'-O-TBDMS-Bz-dA
  • HY-W590551
    Adenosine 5′-O-1-thiotriphosphate
    Adenosine 5′-O-(1-thiotriphosphate) is an α-Phosphate modified adenosine nucleotide.
    Adenosine 5′-O-1-thiotriphosphate
  • HY-152996
    2′-Deoxy-8-(methylthio)adenosine
    2′-Deoxy-8-(methylthio)adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2′-Deoxy-8-(methylthio)adenosine
  • HY-W576440
    α-Cytidine
    		98.68%
    α-Cytidine is a nucleoside. Under appropriate prebiotic conditions, α-Cytidine can be generated from ribose 5'-phosphate, cyanamide and cyanoacetylene.
    α-Cytidine
  • HY-152992
    7-Cyano-7-deaza-2'-deoxy guanosine
    7-Cyano-7-deaza-2'-deoxy guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
    7-Cyano-7-deaza-2'-deoxy guanosine